Clemastine fumarate as a remyelinating therapy for ... | 農藥百科
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由AJGreen著作·2017·被引用313次—Theprimaryefficacyendpointwasmetwithclemastinefumaratetreatment,whichreducedthelatencydelayby1·7ms/eye(95%CI0·5-2·9;p=0· ...
![Clemastine fumarate as a remyelinating therapy for ...](https://i.imgur.com/WMTbIbA.jpg)
Background: Multiple sclerosis is a degenerative inflammatory disease of the CNS characterised by immune-mediated destruction of myelin and progressive neuroaxonal loss. Myelin in the CNS is a specialised extension of the oligodendrocyte plasma membrane and clemastine fumarate can stimulate differentiation of oligodendrocyte precursor cells in vitro, in animal models, and in human cells. We aimed to analyse the efficacy and safety of clemastine fumarate as a treatment for patients with multiple sclerosis.
Methods: We did this single-centre, 150-day, double-blind, randomised, placebo-controlled, crossover trial (ReBUILD) in patients with relapsing multiple sclerosis with chronic demyelinating optic neuropathy on stable immunomodulatory therapy. Patients who fulfilled international panel criteria for diagnosis with disease duration of less than 15 years were eligible. Patients were randomly assign...